Thioredoxin has also been shown to bind to ASK1 to inhibit its action to be a kinase [32]. This inhibition is attenuated by ROS that may result in dimerization of thioredoxin [33]. Thioredoxin regulation from the glucocorticoid receptor by Affiliation for the DNA binding domain has also been documented [34] which as well is motivated by ROS. Extra

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